Histoplasmosis Endophthalmitis – Case Report and Review

Christopher J. Parronchi1, *, Vatsal Doshi2, Ronald G. Nahass1, 3
1 Rutgers-Robert Wood Johnson Medical School, New Brunswick, NJ, USA
2 Vitreous Retina Macula Specialists of New Jersey, Millburn, NJ, USA
3 I.D. Care, Hillsborough, NJ, USA

© 2018 Parronchi et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Rutgers- Robert Wood Johnson Medical School, New Brunswick, NJ USA, Tel: 9082689318; E-mail:



Histoplasma Capsulatum (HC) is one of the most common endemic mycoses in the United States of America, and has also been reported in large numbers in various regions of Central and South America. It can cause disease ranging in severity from an upper respiratory tract-like infection, to deep single organ disease and most concerning, widely disseminated disease resulting in harmful sequelae. Presumed Ocular Histoplasmosis Syndrome (POHS) is the most common ocular manifestation of histoplasmosis and usually results in permanent disability.

Discussion and Conclusion:

In this study, we describe a rarely reported case of histoplasmosis endophthalmitis that was treated with itraconazole and resulted in almost complete resolution of all retinal findings and symptoms.

Keywords: Histoplasma capsulatum, Mycoses , Histoplasmosis endophthalmitis, Itraconazole , Caucasian, Fluorescein angiography.