Vibrio Cholerae Septicemia and Harlequin Ichthyosis: Outstanding Association

Adil Fouad1, *, Fatiha Bennaoui1, Nadia El Idrissi Slitine1, Nabila Soraa2, FMR Maoulainine1
1 Neonatal Intensive Care Unit, Mohamed VI University Hospital, Marrakesh, Morocco
2 Microbiology Department, Mohamed VI University Hospital, Marrakesh, Morocco

© 2018 Fouad et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Neonatal Intensive Care Unit, Mohamed VI University Hospital, PB 2360, Ibn Sina Avenue, Marrakesh, Morocco; Tel: +212661046258; Fax: +212524300700; E-mail:



Harlequin ichthyosis is a rare and fatal fetal disorder, most often complicated by infection. Sepsis due to Vibrio cholerae is rare, especially in neonatology. The association between ichthyosis and Vibrio cholerae infection has never been described in medical literature.


We report the case of a newborn admitted to the neonatal intensive care unit, with a typical characteristics of Harlequin ichthyosis and a sepsis due to Vibrio cholerae, diagnosed with the blood culture. The outcome was fatal; characterized by death six hours after his hospitalization.


Cases of Harlequin ichthyosis complicated with septicemia with Pseudomonas Aeruginosa have been described. Vibrio cholerae infections are usually confined to the gastrointestinal tract but some species, especially non-01 strains, can cause extra-intestinal infections including septicemia and meningitis.

Keywords: Harlequin ichthyosis, Infection, Newborn, Septicemia, Vibrio cholerae, Pseudomonas aeruginosa.