A Current Perspective of Schistosomiasis in Association with Colorectal Carcinogenesis

Eshtiyag Abdalla Abdalkareem1, 2, Khoo Boon Yin1, *
1 Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 Penang, Malaysia
2 Meknimer Street P.O.Box 2404, Tropical Medicine Research Institute (TMRI), Khartoum, Sudan

© 2019 Abdalkareem and Yin.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

* Address correspondence to this author at the Institute for Research in Molecular Medicine (INFORMM), Universiti Sains Malaysia, 11800 Penang, Malaysia; Tel: +604-6534819; E-mails:,



Schistosomiasis is one of the parasitic infections that are often found in humans. More than approximately 200 million people are infected with Schistosomiasis in tropical and subtropical areas of Africa, South America and Asian countries. Literature has long been suggesting the correlation between Schistosomiasis and colorectal malignancy. There is a considerable directory supporting the etiological relation between Schistosoma japonicum infection and colorectal cancer in the Far East, however, the available data about the role of Schistosoma mansoni that can initiate the carcinogenesis of colorectal remain insignificant.


As such, more studies of this disease should be conducted comprehensively for corporate social responsibility internationally.


The present study reviewed the available data about the role of Schistosoma, including S. mansoni in association with the carcinogenesis of colorectal.


The study shows the possible evidence of epidemiology, pathology, molecules and immunopathology associated with Schistosomal infections and colorectal cancer. The infections are apparently getting little attention nor support worldwide due to the geographical barriers and some political issues because it mainly occurs in the people living in the bottom billion and happens in the endemic regions only.


The in-depth study of this infectious disease will tailor early diagnosis, novel prescription drugs and cost-effective strategies for the treatment of infectious disease colorectal cancer, and hence eradicate the disease in the endemic regions.

Keywords: Schistosomiasis, Colorectal cancer, Neglected infectious disease, Schistosoma mansoni, Schistosoma japonicum, Disease eradication.