Aims and Scope
Clarithromycin versus Amoxicillin alone or with Clavulanate in Acute Maxillary Sinusitis: A Meta-analysis of Clinical TrialsDaryl J. Hoban, Jos Nauta
A meta-analysis was performed to explore the relative effects of clarithromycin and amoxicillin (with or without clavulanate potassium) in the treatment of acute maxillary sinusitis.
Six studies were identified in the peer-reviewed literature. All were randomized single-blind (investigator-blind) or open-label trials in outpatients diagnosed with acute maxillary sinusitis. A total of 1580 patients were enrolled, of whom 1194 were clinically evaluable.
The total daily dose of clarithromycin was 1000 mg; the total daily dose of amoxicillin (with or without clavulanate potassium) was either 1500 or 2000 mg. The duration of study drug treatment varied from 8 to 14 days. Endpoints comprised clinical and radiological success within 48 h of the end of study drug treatment plus bacteriologic cure and eradication.
Success and cure rate differences were analyzed using fixed- and random-effect models. The absence of between-study heterogeneity was tested using Cochran’s Q-test.
Clinical success rates varied between 85.8% and 97.9% for clarithromycin and between 84.2% and 96.8% for amoxicillin. The combined rate difference in clinical success rates between clarithromycin and amoxicillin was +1.9% (P=0.14). Radiological success rates (four studies) varied from 78.2% to 94.0% for clarithromycin and 79.7% to 95.0% for amoxicillin, with a combined rate difference of zero (P=1.00). Bacteriologic cure rates (four studies) were 87.1–94.6% for clarithromycin, compared with 89.8–98.1% for amoxicillin, with a combined difference in cure rates of –3.2% (P=0.16). Overall bacterial eradication rates were comparable between the two treatments (clarithromycin, 89.3%; amoxicillin, 92.1%).
These data, with their limitations properly acknowledged, identify clarithromycin as a valid and viable alternative to amoxicillin for the treatment of acute maxillary sinusitis in adults.
April 16, 2021
An Uncommon Presentation of Tuberculosis with Cervical Pott’s Disease Initially Suspected as Metastatic Lung CancerRoberta Buso, Marcello Rattazzi, Massimo Puato, Paolo Pauletto
Cervical Pott's disease is a rare clinical condition whose diagnosis is usually delayed. We report a case of lung tuberculosis (TB) and cervical Pott’s disease mimicking a metastatic lung cancer. The patient presented with persistent cervical pain. Radiologic examinations showed the presence of a lytic lesion of C3 vertebral body, associated with spinal cord compression. A CT scan of the thorax showed a lung nodule highly suspicious for malignancy in the apical region of right lung upper lobe. Neurosurgical decompression was performed. Unexpectedly, histological analysis showed the presence of an inflammatory infiltrate suggestive for TB infection. The patient was immediately treated with antituberculous drugs. Atypical forms of spinal TB, such as cervical TB, can be misdiagnosed as primary or metastatic cancers and lead to delay of treatment initiation that could be fatal. Awareness of this uncommon TB presentation is important to prevent morbidity and mortality associated with spinal cord injury and disease dissemination.
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