Histoplasmosis Endophthalmitis – Case Report and Review

Histoplasma Capsulatum (HC) is one of the most common endemic mycoses in the United States of America, and has also been reported in large numbers in various regions of Central and South America. It can cause disease ranging in severity from an upper respiratory tract-like infection, to deep single organ disease and most concerning, widely disseminated disease resulting in harmful sequelae. Presumed Ocular Histoplasmosis Syndrome (POHS) is the most common ocular manifestation of histoplasmosis and usually results in permanent disability.

In this study, we describe a rarely reported case of histoplasmosis endophthalmitis that was treated with itraconazole and resulted in almost complete resolution of all retinal findings and symptoms.