RESEARCH ARTICLE


Developments in Plant-Based Vaccines Against Diseases of Concern in Developing Countries



Evangelina Gómez, Silvina Chimeno Zoth, Elisa Carrillo, Analía Berinstein*
Instituto de Biotecnología, CICVyA, INTA, Castelar, CC 25 B1712WAA, Buenos Aires, Argentina.

Article Information


Identifiers and Pagination:

Year: 2010
Volume: 4
First Page: 55
Last Page: 62
Publisher Id: TOIDJ-4-55
DOI: 10.2174/1874279301004010055

Article History:

Received Date: 7/9/2009
Revision Received Date: 11/2/2010
Acceptance Date: 9/3/2010
Electronic publication date: 15/9/2010
Collection year: 2010

© 2010 Gómez et al.

open-access license: This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International Public License (CC-BY 4.0), a copy of which is available at: https://creativecommons.org/licenses/by/4.0/legalcode. This license permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Correspondence: * Address correspondence to this author at the Instituto de Biotecnología, CICVyA, INTA, Castelar, CC 25 B1712WAA, Buenos Aires, Argentina. E-mail: aberinstein@cnia.inta.gov.ar


Abstract

Vaccination has been extensively used to prevent, eradicate and control infectious diseases. However, the development and implementation of new vaccines remains prohibitively expensive for middle and low income countries where such measures are surely needed most. The production of plant-based vaccines provides a promising alternative to create affordable biological products. In the past decade, a growing number of research groups worldwide have studied plant expression and parenteral or oral delivery of vaccine antigens, some showing promising potential. Here, we describe the basis of the system and the state of the art of developments regarding diseases of concern in developing countries.

Keywords: Human pathogens, plant-based vaccines, transgenic plants.